Fibromyalgia is a multi-symptom and multi-system disease with chronic widespread pain.
There is evidence that alterations to the endocannabinoid system, which processes pain, the stress response and modulates the immune system, is also involved.
There is a limited efficacy of conventional drugs and poor tolerance of first line drug choices, since people with fibromyalgia tend to experience more severe drug side effects likely due to neuro-immune system differences.